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Mortality associated with enterococcal bacteremia.

C S Bryan, K L Reynolds, J J Brown

    Surgery, Gynecology & Obstetrics
    |June 1, 1985
    PubMed
    Summary
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    Enterococcal bacteremia often indicates severe illness but rarely causes death, except in cases of endocarditis. Antimicrobial therapy did not clearly impact patient outcomes in this study.

    Area of Science:

    • Infectious Diseases
    • Clinical Microbiology
    • Critical Care Medicine

    Background:

    • Enterococcal bacteremia is frequently observed in critically ill patients.
    • Its precise contribution to mortality remains a subject of investigation.
    • Previous studies suggest a significant association with severe disease processes.

    Purpose of the Study:

    • To evaluate the direct mortality attributable to enterococcal bacteremia.
    • To determine the role of enterococcal bacteremia as a cause of death.
    • To assess the impact of antimicrobial therapy on outcomes in enterococcal bacteremia.

    Main Methods:

    • Retrospective analysis of 190 episodes of enterococcal bacteremia in 189 patients.
    • Classification of deaths attributed directly to bacteremia based on predefined criteria.

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  • Review of antimicrobial treatment regimens and their correlation with patient outcomes.
  • Main Results:

    • Overall mortality was 39% (74 out of 189 patients).
    • Only 14 deaths were directly attributed to enterococcal bacteremia.
    • Enterococcal endocarditis was the only clear fatal instance directly caused by the bacteremia.
    • No correlation was found between specific antimicrobial therapy and patient survival.

    Conclusions:

    • Enterococcal bacteremia serves as a marker for serious underlying conditions.
    • Except for endocarditis, enterococcal bacteremia is seldom the direct cause of death.
    • Current antimicrobial strategies did not demonstrate a clear effect on mortality in this cohort.