Related Experiment Video
Updated: May 24, 2025

In vivo Measurement of Knee Extensor Muscle Function in Mice
Published on: March 4, 2021
Getting prepared for the silver wave: challenges in conducting rheumatic and musculoskeletal disease research in
Saskia Truijen1,2, Shennah Austen3,4, Fabienne Magdelijns5
1Department of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands.
Abstract:
Research in older adults diagnosed with rheumatic and musculoskeletal diseases (RMDs) comes with unique challenges, as these patients often face consequences of ageing, such as multimorbidity, polypharmacy, and geriatric syndromes (eg, frailty). In this viewpoint, we highlight various clinical, ethical, regulatory and logistical challenges, including, among others, issues with the decision-making capacity of older adults regarding study participation. We emphasise the need for feasible strategies and protocols to enhance research inclusivity in order to ultimately improve evidence-based care for the growing population of older adults with RMDs.
More Related Videos
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Longitudinal Research
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

