Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ion Exchange01:17

Ion Exchange

520
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
520
Potentiometry: Membrane Electrodes01:15

Potentiometry: Membrane Electrodes

398
Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...
398
Potentiometry: Types of Electrodes01:19

Potentiometry: Types of Electrodes

474
Reference electrodes serve as a stable reference point for potentiometric measurements, while indicator and working electrodes react to variations in the composition of a solution.
The Standard Hydrogen Electrode (SHE) is a widely used reference electrode that maintains zero potential across all temperatures. However, its need for a continuous hydrogen gas supply renders it impractical for everyday use.
An alternative to SHE is the Saturated Calomel Electrode (SCE). This electrode features an...
474
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

398
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
398
Masking and Demasking Agents01:19

Masking and Demasking Agents

2.3K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
2.3K
Formation of Complex Ions03:45

Formation of Complex Ions

23.1K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
23.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One-Year Ultralong Intravitreal Release of Tyrosine Kinase Inhibitor from Supramolecular Temperature-Responsive Hydrogel.

Biomacromolecules·2025
Same author

Biomedically-relevant metal organic framework-hydrogel composites.

Biomaterials science·2023
Same author

Solution-Printable PEDOT Solid-Contact for Nitrate-Selective Electrodes: Enhanced Selectivity from Anion Dopant Exchange.

Analytical chemistry·2022
Same author

Concepts and Emerging Trends for Structural Battery Electrolytes.

Chemistry, an Asian journal·2022
Same author

Halogen Bonding Ionophore for Potentiometric Iodide Sensing.

Analytical chemistry·2021
Same author

Absolute Configuration Determination from Low ee Compounds by the Crystalline Sponge Method. Unusual Conglomerate Formation in a Pre-Determined Crystalline Lattice.

Angewandte Chemie (International ed. in English)·2021

Related Experiment Video

Updated: May 24, 2025

Dynamic Electrochemical Measurement of Chloride Ions
07:32

Dynamic Electrochemical Measurement of Chloride Ions

Published on: February 5, 2016

11.4K

Solution-processable all-solid-state chloride-selective electrode: Enhanced sensitivity from anion dopant exchange.

Shi Hoe Ng1, Georgina E K K Seah1, Dorsasadat Safanama1

  • 1Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A∗STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.

Analytica Chimica Acta
|February 28, 2025
PubMed
Summary

Researchers developed a solution-processable solid-contact ion-selective electrode (SC-ISE) for chloride sensing. Anion exchange improved sensitivity and selectivity, enabling applications in healthcare and scalable anion-selective SC-ISE fabrication.

Keywords:
ChlorideConducting polymerIon sensorIon-selective electrodeSolid contactTransduction layer

More Related Videos

Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research
08:03

Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research

Published on: April 18, 2013

17.2K
Fabrication of Thin Film Silver/Silver Chloride Electrodes with Finely Controlled Single Layer Silver Chloride
07:23

Fabrication of Thin Film Silver/Silver Chloride Electrodes with Finely Controlled Single Layer Silver Chloride

Published on: July 1, 2020

14.0K

Related Experiment Videos

Last Updated: May 24, 2025

Dynamic Electrochemical Measurement of Chloride Ions
07:32

Dynamic Electrochemical Measurement of Chloride Ions

Published on: February 5, 2016

11.4K
Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research
08:03

Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research

Published on: April 18, 2013

17.2K
Fabrication of Thin Film Silver/Silver Chloride Electrodes with Finely Controlled Single Layer Silver Chloride
07:23

Fabrication of Thin Film Silver/Silver Chloride Electrodes with Finely Controlled Single Layer Silver Chloride

Published on: July 1, 2020

14.0K

Area of Science:

  • Electrochemistry
  • Materials Science
  • Analytical Chemistry

Background:

  • Ion-selective electrodes (ISEs) are crucial in various industries.
  • Miniaturization of ISEs involves replacing liquid electrolytes with solid-contacts (SC-ISEs).
  • Solution-processing is preferred for SC-ISE fabrication, but challenges exist for anionic SC-ISEs due to poor solid-contact compatibility.

Purpose of the Study:

  • To develop a fully solution-processable solid-contact for anionic ISEs.
  • To fabricate a chloride (Cl-) SC-ISE using a novel anion exchange method.
  • To investigate the impact of the solid-contact modification on SC-ISE performance.

Main Methods:

  • Fabrication of a poly(3,4-ethylenedioxythiophene)-polyethylene glycol (PEDOT-PEG) solid-contact via anion exchange.
  • Drop-casting of the ion-selective membrane (ISM) onto the modified solid-contact.
  • Electrochemical characterization including sensitivity, selectivity, and dynamic range assessment.
  • Testing in synthetic and real biological samples (sweat, urine, blood).

Main Results:

  • Anion exchange of the PEDOT-PEG solid-contact significantly enhanced SC-ISE sensitivity.
  • The optimal SC-ISE exhibited a near-Nernstian response (-53.3 ± 0.5 mV/decade) for chloride.
  • The SC-ISE demonstrated excellent selectivity against common interfering anions and stability in biological samples.
  • Successful application in sensing chloride in synthetic and real human sweat, urine, and blood samples.

Conclusions:

  • A simple, scalable, and effective anion exchange protocol for solution-processable solid-contacts was developed.
  • This method overcomes limitations in anionic SC-ISE fabrication, improving performance significantly.
  • The developed SC-ISE shows promise for real-world applications, particularly in healthcare monitoring.
  • The protocol can be extended for the scalable preparation of various anion-selective SC-ISEs.