Related Experiment Video

Updated: May 24, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

12.8K

Preventable serious drug-disease interactions of reserve antibiotics

Slobodan M Janković1, Snežana V Janković1, Dobrivoje Stojadinović1

  • 1Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Expert Opinion on Drug Metabolism & Toxicology
|February 28, 2025
PubMed
Abstract

Insights

Reserved antibiotics are crucial for multidrug-resistant infections. Understanding and preventing drug-disease interactions is vital for patient safety, especially in critical care settings.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Reserved antibiotics are critical for treating multidrug-resistant (MDR) and extended-resistant (XDR) bacterial infections.
  • These powerful agents require careful management due to potential serious drug-disease interactions.

Purpose of the Study:

  • To enhance understanding of the risks associated with serious drug-disease interactions involving reserved antibiotics.
  • To present evidence-based strategies for preventing these adverse events.

Main Methods:

  • Comprehensive literature search across major databases (MEDLINE, SCOPUS, EBSCO, Google Scholar).
  • Inclusion of clinical studies, observational human studies, case reports, and case series.
  • No restrictions on publication time or language.

Main Results:

  • Identified and analyzed documented serious drug-disease interactions with reserved antibiotics.
  • Highlighted the critical nature of these interactions in vulnerable patient populations.
  • Emphasized the need for proactive management and monitoring.

Conclusions:

  • Knowledge of drug-disease interactions is essential for safe treatment of critically ill patients with MDR/XDR infections.
  • Implementing routine interaction checks, monitoring excretory organ function, and therapeutic drug monitoring can mitigate risks.
Keywords:
Drug-disease interactionpreventionrenal functionreserve antibioticsserious adverse effect

More Related Videos

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

4.5K
Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

14.1K

Related Concept Videos

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
3.7K
Antibiotic Selection00:57

Antibiotic Selection

Overview
52.1K
Factors Affecting Protein-Drug Binding: Drug Interactions01:23

Factors Affecting Protein-Drug Binding: Drug Interactions

Drug interactions are a critical aspect of pharmacology and can occur when two or more drugs compete for the same binding site. This competition can result in one drug displacing another, altering the effect of the displaced drug. Drug interactions are complex processes that rely heavily on how much of the displacer drug is present and how strongly it can bind to the same sites as the displaced drug.
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
85
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.8K
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
764
Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions01:09

Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions

Renal clearance plays a pivotal role in drug elimination from the body and can be influenced by drug distribution and interactions. Understanding these factors is crucial in pharmacology as they impact the effectiveness and duration of drug therapy.
One important factor is the relationship between renal clearance and the apparent volume of distribution. Renal clearance tends to be inversely proportional to the apparent volume of distribution. Drugs with an extensive distribution volume or those...
80