The role of advanced glycation end products between thyroid function and diabetic nephropathy and metabolic disorders

purpose of this study was to investigate the relationship between AGEs, TSH, metabolic metrics and DN, and to provide evidence for future intervention.

This study selected community health service centers which had signed medical alliance agreement with the First Affiliated Hospital of Anhui Medical University and outpatints and inpatients in Anhui province. From March 2018 to July 2022, the multi-stage cluster sampling. method was used to screen residents aged 18-90 years in the above areas. Participants' blood was collected on an empty stomach to detect TSH, blood lipids, liver and kidney function and blood glucose, in addition, AGEs levels were detected by skin autofluorescence (SAF), and urine was retained to measure the ratio of urinary microalbumin to creatinine concentration by ACR. One-way ANOVA was used to compare the differences between general data, biochemical markers, and urinary ACR, association between variables.

A total of 7000 patients who participated in community health examination and inpatients and also had no history of serious mental disorders were selected. After excluding data with missing value of more than 5%, 6921 samples were finally included, and the effective rate was 94.4%. Following health risk factors (HRFs), such as body mass index (BMI), TSH, low-density lipoprotein (LDL), TyG (triglyceride glucose index), systolic blood pressure (SBP), cholesterol (TC), and uric acid (UA) were associated with a higher incidence of urine ACR. In moderation analysis, there is an significant effect among TSH, AGEs and DN, HRFs moderate also these effect.

The findings suggest that HRFs such as HDL, TyG and TC should be prioritized when evaluating indicators related to DN to effectively reduce DN in Chinese patients with high health risk levels. Comprehensive indicators may be an effective and practical. method to evaluate the metabolic progression of DN. Optimizing thyroid function management may be a new strategy to prevent and treat DN and may help reduce the risk of AGE-related complications in people with diabetes. This study highlights the important role of AGEs in the relationship between TSH and DN. In addition, future studies should further explore how to improve the management and prevention of DN by regulating TSH.Among the leading causes of disability and death in patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes (T2DM), chronic kidney disease (CKD) occupies a certain position. Multi-factor intervention targeting advanced glycation end products (AGEs), blood glucose, blood pressure and lipids can reduce the morbidity and mortality of diabetic nephropathy (DN) in T2DM patients through thyroid stimulating hormone (TSH), which plays an important role in the pathological process of metabolic diseases such as DN. AGEs, as a key factor in metabolic regulation, may affect the formation and function of the thyroid gland; However, in DN, the correlation between AGEs and TSH has not been clarified. We hypothesized that AGEs aggravated the negative effect of TSH on DN. The.