Related Experiment Video

Updated: May 24, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

738

Glycosylated fibronectin in preeclampsia: a systematic review and meta-analysis

Lingyun Liao1,2, Min Liu1,2, Yangxue Yin1,2

  • 1Department of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, (Sichuan University) of Ministry of Education, Chengdu, China.

BMC Pregnancy and Childbirth
|February 28, 2025
PubMed

Insights

Maternal serum glycosylated fibronectin (GlyFn) levels are significantly elevated in preeclampsia (PE) patients. This meta-analysis confirms GlyFn’s high diagnostic accuracy, supporting its use as a biomarker for PE screening and diagnosis.

Area of Science:

  • Reproductive Medicine
  • Biomarkers
  • Diagnostic Accuracy

Background:

  • Preeclampsia (PE) is a serious pregnancy complication impacting maternal and infant health.
  • Elevated maternal serum glycosylated fibronectin (GlyFn) has been observed in PE patients.
  • GlyFn shows potential as a novel biomarker for PE screening and diagnosis.

Purpose of the Study:

  • To evaluate maternal serum GlyFn levels in preeclampsia.
  • To assess the diagnostic accuracy of GlyFn for preeclampsia.

Main Methods:

  • Systematic literature search of PubMed, EMBASE, Web of Science, and Cochrane Library.
  • Meta-analysis of 11 studies comparing maternal serum GlyFn levels in PE vs. controls.
  • Assessed diagnostic accuracy using pooled sensitivity, specificity, and area under the curve (AUC).

Main Results:

  • Maternal serum GlyFn levels were significantly higher in the PE group (SMD = 1.08).
  • The pooled sensitivity for GlyFn in diagnosing PE was 0.81.
  • The pooled specificity was 0.80, with an AUC of 0.90.

Conclusions:

  • Maternal serum GlyFn levels are significantly elevated in preeclampsia.
  • GlyFn demonstrates high diagnostic accuracy for preeclampsia.
  • GlyFn is a promising biomarker for PE screening and diagnosis.
Abstract

Keywords:
DiagnosisGlycosylated fibronectinMeta-analysisPreeclampsiaSystematic review

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