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Updated: May 24, 2025
04:12
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
Published on: January 19, 2024
762
Pathogenesis of Melasma Explained.
1Barking, Havering and Redbridge University Hospitals NHS Trust, Romford, United Kingdom.
International Journal of Dermatology
|March 1, 2025
Summary
This review details melasma pathophysiology, including epidermal, basement membrane, and dermal changes. Understanding these mechanisms is key for developing effective treatments for this common skin condition.
Area of Science:
- Dermatology
- Pathophysiology
- Skin Biology
Background:
- Melasma is a prevalent hyperpigmentation disorder.
- Understanding its pathogenesis is crucial for effective treatment development.
Purpose of the Study:
- To provide an in-depth analysis of melasma pathophysiology.
- To highlight recent studies on its underlying mechanisms.
- To review current treatment approaches.
Main Methods:
- Literature analysis of epidermal, basement membrane, and dermal changes.
- Examination of visible light and hormonal influences.
- Survey of contemporary and emerging treatments.
Main Results:
- Significant epidermal and basement membrane alterations in melasma.
- Dermal factors include vascular changes, mast cell activity, and senescent fibroblasts.
- Visible light and hormonal fluctuations play a role.
Conclusions:
- Advancements in understanding melasma pathophysiology are evident.
- Novel therapeutic modalities targeting these mechanisms are under investigation.
- Continued research is essential for optimizing clinical outcomes.
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