Cerebral amyloid angiopathy associated with giant cell arteritis: a case report

A case of cerebral amyloid angiopathy associated with granulomatous arteritis is presented with description of the microscopic, immunocytochemical and ultrastructural features. The amyloid proved to be of the AL-type, with failure to show reactivity with anti-AA, anti-prealbumin and anti-albumin. Antisera against SAP and IgG (AF) did show reactivity. Hence the immunologic characteristics of this amyloid differ from those of other known conditions and may therefore represent a new form of amyloid. The role of granulomatous arteritis in this case remains speculative.