Predictors of status epilepticus among older adults - a prospective real-world study

Data on status epilepticus (SE) in older inpatients is limited.

To assess SE characteristics and etiologies, and identify risk factors for SE in a cohort of hospitalized patients.

We selected patients aged ≥ 60 years with late-onset seizures from a tertiary center. We analyzed demographics, clinical characteristics, etiology of seizures, neurological diseases, and comorbidities. We performed the Kaplan-Meier analysis to examine acute symptomatic and unprovoked seizures and multivariate logistic regression to identify risk factors for SE.

We enrolled 236 patients (mean age: 77.1 ± 9.7 years [SD]) with acute symptomatic seizures, unprovoked seizures and both. SE occurred in 61 (25.8 %) patients. The mean age at the first-ever seizure was 76.5 ± 9.8 years. Females comprised 62.3 % of the patients in the SE group. Convulsive SE was the most common presentation (80.3 %). Cerebrovascular disorders were the most common etiology (27.9 %) among patients with SE. The likelihood of SE occurring was similar between patients with acute symptomatic seizures alone or in combination with unprovoked seizures (118/50 %), and those with unprovoked seizures (118/50 %). Dyslipidemia negatively correlated with SE (OR 0.45 [95 % CI, 0.24-0.85]; p = 0.014), perhaps due to statin use. Psychiatric disorders (OR 2.76 [95 % CI, 1.45-5.24]; p = 0.002;), sepsis (OR 2.33 [95 % CI, 1.13-4.79]; p = 0.021), and congestive heart failure (OR 2.95 [95 % CI,1.07-8.12]; p = 0.036) were risk factors for SE.

We identified older inpatients who developed SE, their characteristics, and the risk factors for developing SE.