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Pattern-VEP findings in individuals with mild cognitive impairment
Mesude Kisli1, Hikmet Saçmacı2
1Department of Neurology, Sivas State Hospital, Sivas, Turkey.
Behavioural Brain Research
|March 1, 2025
Summary
Visual evoked potential (VEP) tests reveal delayed brain responses in individuals with mild cognitive impairment (MCI). VEP parameters also correlate with cognitive function, suggesting VEP
Area of Science:
- Neuroscience
- Ophthalmology
- Geriatrics
Background:
- Mild cognitive impairment (MCI) affects neural pathways.
- Visual evoked potential (VEP) assesses brain electrical activity in response to visual stimuli.
- VEP may detect visual pathway abnormalities in MCI.
Purpose of the Study:
- To evaluate visual pathway neural transmission using VEP in MCI patients.
- To compare VEP parameters between MCI individuals and healthy controls.
- To investigate correlations between VEP measures and cognitive domains.
Main Methods:
- Pattern-reversal VEP was used.
- 56 MCI patients and 50 healthy controls (aged 60-80) participated.
- Cognitive function assessed using Mini-Mental State Examination (MMSE).
Main Results:
- MCI patients exhibited significantly longer left P100 latency compared to controls.
- VEP amplitudes (N75-P100 and P100-N145) positively correlated with MMSE recall scores.
- These findings suggest VEP alterations in MCI.
Conclusions:
- Pattern VEP, combined with clinical parameters, can aid in evaluating MCI.
- VEP interpeak amplitudes are important indicators in MCI patients, correlating with cognitive recall.
- VEP shows potential as a diagnostic tool for MCI.
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