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Plant-derived nanovesicles and therapeutic application.

Dokyung Jung1, Na-Eun Kim1, Sua Kim1

  • 1Department of Molecular Medicine, CMRI, Exosome Convergence Research Center (ECRC), School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.

Pharmacology & Therapeutics
|March 1, 2025
PubMed
Summary

Plant-derived nanovesicles (PDNVs) offer a promising, low-toxicity platform for drug delivery and therapeutics. Research highlights methods for isolating, characterizing, and engineering PDNVs for diverse clinical applications.

Keywords:
Drug delivery systemsIsolation methodsPlant-derived nanovesiclesTherapeutic agentsTherapeutic applications

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Plant Science

Background:

  • Plant-derived nanovesicles (PDNVs) are emerging as valuable therapeutic tools due to their biocompatibility and low toxicity.
  • Their cost-effectiveness and inherent diversity make them attractive for various biomedical applications.

Purpose of the Study:

  • To review methods for isolating and characterizing PDNVs.
  • To emphasize the therapeutic potential and drug delivery capabilities of PDNVs.
  • To discuss advanced engineering strategies and future challenges in PDNV research.

Main Methods:

  • Isolation and characterization techniques for PDNVs.
  • Evaluation of PDNVs for encapsulating and delivering nucleic acids, proteins, and small molecules.
  • Exploration of surface modification and vesicle fusion for enhanced therapeutic effects.

Main Results:

  • PDNVs demonstrate effective encapsulation and delivery of diverse therapeutic payloads.
  • Engineering strategies can significantly enhance the therapeutic efficacy of PDNVs.
  • PDNVs show potential for direct therapeutic applications and sophisticated drug delivery systems.

Conclusions:

  • PDNVs represent a versatile and promising platform for advanced therapeutics and drug delivery.
  • Further research is needed to overcome current challenges and optimize PDNVs for clinical use.
  • PDNVs are poised to contribute significantly to personalized medicine and innovative therapeutic strategies.