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Updated: May 24, 2025

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
Published on: May 9, 2025
[Targeting the TGF-β pathway in pulmonary fibrosis: Is it still a relevant strategy?]
L Biziorek1, M Dériot1, P Bonniaud2
1Université Bourgogne Europe, INSERM U1231 Center for Translational and Molecular Medicine (CTM), UFR des Sciences de Santé, Dijon, France.
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a rare, progressive and fatal disease without pharmacologic curative treatments for the patients. TGF-β is a crucial cytokine in the fibrotic process, and its intracellular signaling pathways are complex and rely on the activation of its receptor. This review summarizes our knowledge on the regulatory checkpoints of the TGF-β signaling. In addition, the main strategies and key potential therapeutic targets identified over recent years are presented, with particular emphasis laid on how they can be used to develop new treatments for pulmonary fibrosis.
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