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Emerging glucose oxidase-delivering nanomedicines for enhanced tumor therapy
Kaiyue Song1, Jiang Ming2, Bailong Tao3
1Jiangxi Provincial Key Laboratory of Organic Functional Molecules, Institute of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China.
Abstract:
Abnormalities in glucose metabolism have been shown to characterize malignant tumors. Glucose depletion by glucose oxidase (GOD) has shown great potential in tumor therapy by causing tumor starvation. Since 2017, nanomedicines have been designed and utilized to deliver GOD for more precise and effective glucose modulation, which can overcome intrinsic limitations of different cancer therapeutic modalities by remodeling the tumor microenvironment to enhance antitumor therapy. To date, the topic of GOD-delivering nanomedicines for enhancing tumor therapy has not been comprehensively summarized. Herein, this review aims to provide an overview and discuss in detail recent advances in GOD delivery and directly involved starvation therapy strategies, GOD-sensitized various tumor therapy strategies, and GOD-mediated multimodal antitumor strategies. Finally, the challenges and outlooks for the future progress of the emerging tumor therapeutic nanomedicines are discussed. This review provides intuitive and specific insights to a broad audience in the fields of nanomedicines, biomaterials, and cancer therapy.
Insights
Nanomedicines deliver glucose oxidase (GOD) to deplete tumor glucose, enhancing cancer therapy by starving malignant cells. This review summarizes recent advances in GOD-delivering nanomedicines for improved antitumor strategies.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Malignant tumors exhibit altered glucose metabolism.
- Glucose oxidase (GOD) therapy depletes tumor glucose, inducing starvation.
- Nanomedicines offer precise delivery of GOD for enhanced glucose modulation.
Purpose of the Study:
- To comprehensively review nanomedicines delivering GOD for tumor therapy.
- To discuss advances in GOD delivery, starvation therapy, and sensitized/multimodal antitumor strategies.
- To explore challenges and future directions for GOD-delivering nanomedicines.
Main Methods:
- Literature review of nanomedicine applications in glucose oxidase delivery.
- Analysis of GOD-based starvation therapy and its integration with other cancer treatments.
- Discussion of nanomedicine-mediated remodeling of the tumor microenvironment.
Main Results:
- Nanomedicines enable targeted delivery of GOD, overcoming limitations of traditional therapies.
- GOD-delivering nanomedicines enhance antitumor effects by modulating tumor glucose levels.
- Integration of GOD nanomedicines with other modalities shows promise for multimodal cancer therapy.
Conclusions:
- GOD-delivering nanomedicines represent a promising strategy for cancer therapy.
- Further research is needed to address challenges and optimize therapeutic outcomes.
- This field holds significant potential for advancing nanomedicine and cancer treatment.
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