Related Experiment Video
Updated: May 24, 2025

Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry
Published on: August 23, 2022
Ion-Pair Extraction with Tetracyanocyclopentadienides: A Method for Estimating Extraction Efficiency
Takeo Sakai1, Masanari Ota1, Miho Ito1
1Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
Abstract:
Ion-pair extraction with tetracyanocyclopentadienides (TCCPs) is an effective method for isolating ammonium cations; however, predicting the extractability of ammonium-TCCP ion pairs is challenging. Herein, the measured extraction coefficients (LogKex) of ammonium-TCCP ion pairs allowed the values of A (an index for anion extractability) for the TCCP anions to be determined (-3.1 to -1.4); these values were higher than and similar to those of perchlorate and picrate anions, respectively. The correlation between LogKex and the sum of the values of A and the calculated Log P of ammonium cations revealed that LogKex can be estimated by the equation LogKex = A + CLOGPNR4 + 1.6, where CLOGPNR4 is the CLOGP value obtained using the "no-plus" ammonium structure. The LogKex value can be used to predict the extractability of quaternary ammonium ions.
Related Concept Videos
Extraction: Advanced Methods
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

