Oral plasmacytoma in multiple myeloma patients: report of 18 cases
Lama Alabdulaaly1, Maryam Jessri1, Nathaniel Treister2
1Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA; Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.
Objectives:
Plasmacytoma is a malignant neoplasm of plasma cells with or without an underlying multiple myeloma (MM). Plasmacytoma rarely involves the oral mucosa and jaw bones. We aimed to describe oral plasmacytoma in MM patients.
Study Design:
Patients with oral plasmacytoma seen at the Oral Medicine clinic from 2007 to 2024 were included in this study.
Results:
There were 18 patients (26 oral plasmacytomas). The median age was 60.5 years (72.3% females). The most common symptoms were pain and bleeding. Ten patients had gnathic involvement, and 8 patients had soft tissue disease without bony involvement. The gingiva was the most common site (50.0%) and buccolingual involvement was seen in 38.5% of cases. Treatment directed at the oral disease was rendered in 11 patients. Over 90% of patients died with a median of 5 months.
Conclusions:
MM patients may present with oral involvement most commonly on the gingiva with frequent buccal and lingual involvement.
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