Importance of assessing erectile dysfunction in patients with type 2 diabetes mellitus based on glucose fluctuation:
Shenhang Yao1,2, Shimei Xing1,2, Xiangxiang Shan1,2
1Department of Endocrinology, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, People's Republic of China.
Purpose:
To investigate the relationship between glucose fluctuation and erectile dysfunction (ED) in patients with type 2 diabetes mellitus (T2DM).
Methods:
This cross-sectional study included 317 male patients with T2DM. Participants were categorized into non-ED group (76 cases) and ED group (241 cases) based on International Index of Erectile Function-5 (IIEF-5) scores. Patients were additionally segmented into quartiles based on time in range (TIR). Demographic and laboratory data were collected, and glucose fluctuation indicators were ascertained using flash glucose monitoring.
Results:
The ED group exhibited significantly lower TIR and IIEF-5 scores compared to the non-ED group (P < 0.05). An increase in TIR levels corresponded with higher IIEF-5 scores and a significant reduction in ED incidence (P < 0.05). Spearman's correlation analysis indicated a positive correlation between IIEF-5 scores and TIR (r = 0.48, P < 0.01). Restricted cubic spline analysis revealed a negative linear association between TIR and ED (P for linearity <0.05). Multivariate logistic regression analysis, after adjusting for confounding factors, confirmed that low TIR is an independent risk factor for ED (P < 0.05).
Conclusion:
Glucose fluctuation in T2DM patients correlate with ED, with low TIR being independently and positively associated with ED incidence, suggesting it may be a significant risk factor for ED in patients with T2DM.
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