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Associations between shift work and biological age acceleration: A population-based study.

Jia-Ning Wang1, Wei Hu1, Bao-Peng Liu2

  • 1Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

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|March 2, 2025
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Summary
This summary is machine-generated.

Shift work, especially night shifts, is linked to accelerated biological aging. This effect is more pronounced in males and those with poor sleep, highlighting the need for better work scheduling.

Keywords:
Biological age accelerationNight shift workShift workUK Biobank

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Area of Science:

  • Chronobiology
  • Gerontology
  • Occupational Health

Background:

  • Shift work is prevalent and may impact health.
  • Biological age acceleration (BAA) is a marker of aging and disease risk.
  • Understanding factors influencing BAA is crucial for public health.

Purpose of the Study:

  • To investigate the association between shift work and biological age acceleration.
  • To identify potential moderating factors influencing this relationship.

Main Methods:

  • Population-based study using UK Biobank data (N=195,419).
  • Biological age assessed using Klemera-Doubal method (KDM-BA) and Phenotypic Age (PhenoAge).
  • BAA calculated as residuals from regressing biological age on chronological age.

Main Results:

  • Shift work (16.1%) and night shift work (8.1%) were associated with increased BAA.
  • Irregular and permanent night shifts showed higher risks.
  • Greater BAA risks observed in younger individuals, males, those with high BMI, or poor sleep.

Conclusions:

  • Shift work is a significant risk factor for biological age acceleration.
  • Targeted interventions and optimized work scheduling are needed.
  • High-risk populations require specific attention to mitigate adverse aging effects.