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Lysosomal Hydrolases01:22

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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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Evaluating large language models in pediatric nephrology

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  • 1Department of Paediatrics, Schulich School of Medicine & Dentistry, Children's Hospital of Western Ontario, University of Western Ontario, 800 Commissioners Road East, London, ON, N6A 5W9, Canada. guido.filler@lhsc.on.ca.

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