Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ershiwuwei Shanhu Pill ameliorates cognitive impairment in Alzheimer's disease mice by remodeling gut microbiota and host serum metabolites.

Frontiers in aging neuroscience·2026
Same author

Efficacy of transcranial direct current stimulation for post-stroke urinary incontinence: study protocol for a randomized controlled trial.

Trials·2026
Same author

Neuroprotective effects of Ershiwuwei Shanhu pills on APP/PS1 mice through antioxidant enhancement, anti-apoptosis, and MAPK pathway regulation.

Translational neuroscience·2026
Same author

Statistical method for pooling categorical biomarker data from multi-center matched/nested case-control studies.

The international journal of biostatistics·2026
Same author

[Mechanism of Shuxiong Prescription in treating non-alcoholic fatty liver disease in rats based on theory of "treatment of different diseases with same approach"].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same author

Effects of a low-load multi-component training program with blood flow restriction versus the same program without blood flow restriction on muscle thickness and functional outcomes in physically inactive young adults: randomized controlled trial.

Frontiers in physiology·2026

Related Experiment Video

Updated: May 24, 2025

Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents
05:04

Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents

Published on: July 21, 2022

1.7K

Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia.

Qing Zhang1, Yangjie Xu1, Haodong Luo1

  • 1Department of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Chongqing, 400000, China.

Neurochemical Research
|March 2, 2025
PubMed
Summary

High-intensity treadmill training promotes myelin repair and functional recovery after acute hypoxia exposure in rats. This physical therapy enhances oligodendrocyte maturation and nerve conduction by upregulating PGC1α and cholesterol synthesis pathways.

Keywords:
Cholesterol synthesisCognitive functionHypobaric hypoxiaPGC1αRemyelination

More Related Videos

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
08:57

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

26.9K
Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats
06:40

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats

Published on: January 16, 2019

8.0K

Related Experiment Videos

Last Updated: May 24, 2025

Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents
05:04

Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents

Published on: July 21, 2022

1.7K
Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
08:57

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

26.9K
Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats
06:40

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats

Published on: January 16, 2019

8.0K

Area of Science:

  • Neuroscience
  • Exercise Physiology
  • Cell Biology

Background:

  • High altitude exposure causes neurological damage, with limited understanding of physical therapy's role in myelin repair.
  • Existing research focuses on pharmacological interventions, leaving exercise-induced recovery mechanisms unclear.

Purpose of the Study:

  • To investigate the efficacy of varied intensity treadmill training on myelin repair and functional recovery following acute hypobaric hypoxia (HH) in a rat model.
  • To elucidate the underlying molecular mechanisms, including oligodendrocyte maturation and specific pathway activation.

Main Methods:

  • Rats were subjected to acute hypobaric hypoxia and then underwent 4 weeks of treadmill training at 30%, 50%, or 70% maximum speed.
  • Oligodendrocyte morphometry, myelin-related protein expression, and myelin sheath structure were assessed using immunofluorescence, western blotting, and transmission electron microscopy.
  • Cognitive and mood functions were evaluated using open field, elevated plus maze, and Morris water maze tests.

Main Results:

  • Acute hypoxia induced demyelination in the cortex and hippocampus.
  • High-intensity treadmill training significantly enhanced oligodendrocyte maturation, myelin protein expression, and myelin sheath thickness.
  • This intervention improved cognitive function, reduced mood disorders, and preserved nerve conduction.

Conclusions:

  • High-intensity treadmill training effectively promotes myelin repair and functional restoration after acute hypoxia-induced injury.
  • The benefits are mediated through the upregulation of PGC1α and key cholesterol synthesis enzymes, highlighting a novel therapeutic pathway for remyelination.
  • Exercise, particularly high-intensity training, offers a promising physical therapy approach for neurological rehabilitation after hypoxia.