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Elevated atherogenic index of plasma is associated with increased cardiorenal syndrome prevalence: a cross-sectional

Sikai Xu1, Jianping Hu2, Zhiyi Ouyang3

  • 1Department of Medical Genetics, the Second Affiliated Hospital of Nanchang University, Nanchang, China.

Renal Failure
|March 3, 2025
PubMed

Insights

Higher atherogenic index of plasma (AIP) is linked to increased cardiorenal syndrome (CRS) risk. This association was stronger in individuals without hypertension, suggesting AIP as a potential biomarker for CRS.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Cardiorenal syndrome (CRS) involves simultaneous heart and kidney dysfunction.
  • Atherogenic index of plasma (AIP), derived from triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C), is a potential cardiovascular risk marker.

Purpose of the Study:

  • To investigate the association between AIP and CRS.
  • To explore the potential linkage between AIP and CRS in a large population cohort.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (2005-2018) with 35,365 participants.
  • Defined CRS by coexisting cardiovascular disease (CVD) and chronic kidney disease (CKD).
  • Employed weighted logistic regression and restricted cubic spline (RCS) analysis, adjusting for covariates.

Main Results:

  • A positive correlation was observed between AIP and CRS across all models.
  • The highest AIP quartile showed a significantly increased odds ratio (OR) for CRS (OR = 1.62).
  • RCS analysis confirmed a positive AIP-CRS correlation; TG correlated positively, HDL-C negatively with CRS. A significant interaction with hypertension was noted, with a stronger association in non-hypertensive individuals.

Conclusions:

  • Elevated AIP levels are associated with a higher prevalence of CRS.
  • The study highlights a significant interaction with hypertension, indicating a greater effect of AIP on CRS in non-hypertensive individuals.
Abstract

Keywords:
Atherogenic Index of PlasmaCardiorenal syndromedyslipidemiahigh-density lipoprotein cholesteroltriglycerides

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