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Related Concept Videos

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Decoding the Nectin Interactome: Implications for Brain Development, Plasticity, and Neurological Disorders.

Shreyash Santosh Yadav1, Krishnamoorthy Srinivasan2,3, Shyam Sunder Sharma2

  • 1Molecular NeuroTherapeutics Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Uttar Pradesh 226002, India.

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Summary
This summary is machine-generated.

Nectin cell adhesion molecules are crucial for brain development and function, regulating neural processes and connectivity. Their dysregulation is linked to neurological disorders, suggesting therapeutic potential.

Keywords:
NMDANectincell adhesion moleculecognitionneuronal circuitsynaptic plasticity

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Nectin family of cell adhesion molecules (CAMs) are key regulators of neural processes.
  • They mediate cell-cell adhesion through homophilic and heterophilic interactions, crucial for neural circuits.
  • Nectins play roles in neuronal development, migration, synapse formation, and plasticity.

Purpose of the Study:

  • To review the structural and functional characteristics of nectins.
  • To examine their distribution and molecular mechanisms in neural connectivity and cognition.
  • To discuss nectin-mediated pathophysiology and potential therapeutic interventions.

Main Methods:

  • Literature review of structural and functional characteristics.
  • Analysis of experimental studies on nectin-mediated pathophysiology.
  • Exploration of therapeutic interventions targeting nectin-related pathways.

Main Results:

  • Nectins are vital for establishing and maintaining neural circuits via cell-cell adhesion.
  • Their distinct localization in neurons, astrocytes, and the blood-brain barrier highlights diverse brain functions.
  • Dysregulation of nectins is implicated in neurological disorders like Alzheimer's disease and schizophrenia.

Conclusions:

  • Nectins are significant in brain development, function, and disease.
  • Understanding nectin pathways offers potential for novel therapeutic strategies.
  • This review provides insights for future research and clinical applications in neuroscience.