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Illuminating a Dark Kinase in the Mesenchymal Cancer Cell State

Shensi Shen1, Zhen Tan2

  • 1Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.

Cancer Discovery
|March 3, 2025
PubMed
Summary

Protein kinase N2 (PKN2) drives cancer cell survival and drug resistance by activating YAP/TAZ. Targeting PKN2 may eliminate drug-tolerant cancer cells when combined with existing therapies.

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