Related Experiment Video
Updated: May 24, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
Two Faces of NOTCH1 in Liver Cancer and Immunotherapy
Jiani Zhu1,2, Ekaterina K Koltsova1,2
1Department of Medicine, Cedars-Sinai Medical Center, Cedars-Sinai Cancer Institute, Los Angeles, California.
None:
High NOTCH1 expression inversely correlates with hepatocellular carcinoma tumorigenicity and contributes to better immune checkpoint inhibitor responses in male patients, whereas high NOTCH1 in females coincides with heightened hepatocellular carcinoma incidence and poor immunotherapy responses. Activated NOTCH1 generates enhanced antitumor CD8+ T-cell responses in a sex chromosome-dependent manner and facilitates responsiveness to immunotherapy treatment in males, whereas it drives immune escape in females. See related article by Lindblad et al., p. 495.
More Related Videos
Related Concept Videos
Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Tumor Immunotherapy
Abnormal Proliferation
Non-Canonical Wnt Signaling Pathways

