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This study developed a photo-responsive nerve conduit using zinc-citric acid MOFs and H2S. It effectively regulates the microenvironment, promoting nerve regeneration and motor function recovery after injury.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Neuroscience

Background:

  • Nerve injury disrupts the microenvironment, hindering regeneration due to inflammation, oxidative stress, and poor vascularization.
  • Conventional drug delivery via nerve conduits faces challenges like the blood-nerve barrier and lack of multifunctionality.
  • Multifunctional conduits are crucial for timely and effective regulation of the nerve regeneration microenvironment.

Purpose of the Study:

  • To develop a photo-responsive, multifunctional nerve conduit for enhanced nerve regeneration.
  • To investigate the combined therapeutic effects of hydrogen sulfide (H2S) and zinc ions (Zn2+) on the nerve regeneration microenvironment.
  • To improve conduit performance through RGD modification and aligned structure.

Main Methods:

  • Fabrication of a photo-responsive H2S-releasing composite nerve conduit using zinc-citric acid metal-organic frameworks (Zn-CA MOFs).
  • Modification of polyester amide conduits with RGD peptides and incorporation of an aligned structure.
  • Assessment of the conduit's ability to regulate inflammation, oxidative stress, mitochondrial function, and angiogenesis.
  • Evaluation of cell adhesion and guided migration on the aligned conduit structure.

Main Results:

  • The developed conduit effectively releases H2S and Zn2+, jointly regulating the inflammatory and oxidative stress responses.
  • H2S and Zn2+ promoted mitochondrial function recovery and enhanced angiogenesis, crucial for nerve repair.
  • The aligned structure and RGD modification improved cell adhesion and directed cell migration.
  • The composite conduit demonstrated significant acceleration of nerve regeneration and restoration of motor function.

Conclusions:

  • This study presents a novel approach combining gas neurotransmitters (H2S) and ions (Zn2+) within a multifunctional nerve conduit.
  • The developed photo-responsive conduit effectively modulates the regeneration microenvironment, promoting nerve repair and functional recovery.
  • This strategy offers a promising therapeutic avenue for treating nerve injuries.