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On Paper Diagnostics: A Brief History and Future Perspectives
Nathan Khosla1, Andrew DeMello2, Daniel Richards3
1Institute for Chemical and Bioengineering, ETH Zurich, Vladimir-Prelog-Weg 1, CH-8093 Zürich, Switzerland. nathan.khosla@chem.ethz.ch.
Chimia
|March 3, 2025
Summary
Paper-based diagnostics offer accessible healthcare solutions by simplifying complex tests for point-of-care use. This technology addresses global health disparities by enabling easy-to-use, low-cost diagnostic tools.
Area of Science:
- Biochemistry
- Chemistry
- Engineering
- Medical Diagnostics
Background:
- Diagnostic technologies are crucial for patient health assessment and disease identification.
- Advancements in science and engineering have accelerated diagnostic technology development.
- Increased complexity has led to centralized labs, causing healthcare disparities.
Purpose of the Study:
- To review the interdisciplinary development of paper-based diagnostics.
- To detail their journey from concept to commercial success.
- To discuss the current state-of-the-art and future potential.
Main Methods:
- Review of interdisciplinary innovations in paper-based diagnostics.
- Analysis of market introduction and commercialization pathways.
- Assessment of current technological capabilities and limitations.
Main Results:
- Paper-based diagnostics leverage interdisciplinary advances for simplified assays.
- New formats enable point-of-care (PoC) and at-home testing.
- Commercial successes demonstrate market viability.
Conclusions:
- Paper-based diagnostics are shifting the paradigm towards decentralized healthcare.
- Further improvements can enable more complex chemistries on simple platforms.
- These devices hold promise for reducing global healthcare disparities.
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