Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis Following SARS-CoV-2 Vaccination

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune demyelinating disorder that occurs in approximately 20% of cases in a postinfectious or postvaccination context. To date, few cases of MOGAD have been reported following SARS-CoV-2 immunization. Here, we report the case of a 28-year-old female presenting with isolated unilateral optic neuritis, achieving complete recovery after corticosteroid treatment. To the best of our knowledge, this represents the second reported case of MOGAD following the mRNA-1273 vaccine and the first presenting as isolated and unilateral optic neuritis.