Exosomes-based liquid biopsy: An effective approach for drugs and therapeutics resistance screening in cancer

Cancer drugs and therapeutics resistance are a complicated domain of cancer treatment. Extracellular vesicles (EVs) based cancer investigation reveals several complicated concepts about cancer. EVs are associated with cellular communication. Its bioactive molecular transportation reprograms cellular activity. Exosomes an exciting EVs subpopulation work as masterminds in cancer development and progression. Studies over the past decade have elucidated that exosomes play a vital role in intercellular communication within the tumor microenvironment (TME), influencing multiple events such as hypoxia-induced epithelial-mesenchymal transition (EMT), cancer stemness, angiogenesis, and metastasis. Tumor-derived exosomes (TEXs) associated with drugs and therapeutics resistance development. This article focuses on understanding exosome biology and its implications in cancer drug and therapeutics resistance, exosome-based liquid biopsy application in drug and therapeutic resistance detection, limitations, and future orientation in this domain.