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Exploring the Plasma Proteome: Identifying Hub Proteins linking Aging, Homeostasis, and Organ Function
Juan Jiao1, Fei Gao2, Hongye Zhao3
1Department of Clinical Laboratory, the Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, P.R. China.
Plasma proteins reflect organism aging and homeostasis. This study identified 20 aging-related hub proteins involved in oxidative stress, inflammation, and metabolism, linking them to physiological health across the lifespan.
Area of Science:
- Gerontology
- Proteomics
- Biochemistry
Background:
- Plasma proteins are key effectors of gene-environment interactions, monitoring homeostasis and reflecting organismal aging.
- Biomarkers linking aging and homeostasis require further elucidation.
Purpose of the Study:
- To investigate phenotype-related plasma proteome profiles in healthy individuals.
- To identify proteins specifically associated with aging and physiological indices across the lifespan.
Main Methods:
- Cross-sectional study of 71 participants aged 20-100 years.
- Plasma proteome analysis to identify aging-related proteins and their expression patterns.
- Hub protein screening via correlation with physiological and biochemical phenotypes.
Main Results:
- Plasma protein levels correlate with age and physiological indices.
- Identified 20 hub proteins associated with both age and physiological indices.
- These proteins are involved in oxidative stress, inflammation, and metabolism, with 8 confirmed to mediate homeostasis and organ function.
Conclusions:
- Plasma proteins associated with both aging and physiological indices are implicated in oxidative stress, inflammation, and metabolism.
- This study establishes a novel link between aging, homeostasis, and plasma protein profiles.
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