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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

159
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
159
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

151
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
151
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

772
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
772
Pneumothorax-I01:26

Pneumothorax-I

166
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
166
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

22
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
22
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

116
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
116

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Related Experiment Video

Updated: May 24, 2025

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
08:54

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Published on: October 22, 2019

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Neurological Crisis Following Intravenous Ozone Therapy; a Case Report.

Chloe Y Y Wong1, Komal Saxena1, John Meneer1

  • 1Department of Emergency Medicine, Gold Coast University Hospital, Southport, Queensland, Australia.

Archives of Academic Emergency Medicine
|March 3, 2025
PubMed
Summary

Ozone therapy, an unproven alternative treatment, can cause severe neurological damage, including stroke and lasting cognitive deficits. Regulatory agencies warn against its use due to safety risks and lack of efficacy.

Keywords:
AirComplementary TherapiesEmbolismEmergency ServiceHospitalNeurologyOzone

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Area of Science:

  • Neurology
  • Toxicology
  • Alternative Medicine

Background:

  • Ozone therapy is promoted as an immune-boosting alternative treatment.
  • Its efficacy is not well-established, and significant safety concerns exist.
  • Regulatory bodies like the FDA advise against its use due to toxicity.

Observation:

  • A case report details severe neurological complications in a patient after intravenous ozone therapy.
  • The patient, a 36-year-old woman, experienced chest pain, syncope, and seizures post-treatment.
  • Imaging confirmed multiple ischemic infarcts in the thalamus and cerebellum.

Findings:

  • Intravenous ozone therapy led to embolic events causing ischemic infarcts.
  • The patient suffered persistent cognitive impairments requiring extensive rehabilitation.
  • This case underscores the severe risks associated with ozone therapy.

Implications:

  • Highlights the potential neurotoxicity of ozone therapy.
  • Emphasizes the need for caution regarding unproven alternative treatments.
  • Supports regulatory warnings against the use of ozone therapy due to safety risks.