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Cancer-associated macrophage-like cells as a prognostic biomarker in solid tumors

  • 0Li Ka Shing Cell and Gene Therapy Program, The University of Sydney, Camperdown, 2050, NSW, Australia.
The Journal of Liquid Biopsy +

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March 3, 2025

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March 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Cancer-associated macrophage-like cells (CAMLs) are novel blood biomarkers for solid tumors. This review explores their potential for cancer prognostication and treatment monitoring.

Area Of Science

  • Oncology
  • Hematology
  • Immunology

Background

  • Cancer-associated macrophage-like cells (CAMLs) are myeloid cells found in blood, linked to cancer.
  • CAMLs are emerging as potential liquid biopsy biomarkers for solid tumors.
  • These cells have been detected in various cancers but not in healthy individuals.

Purpose Of The Study

  • To review current studies on CAMLs.
  • To explore the future clinical utility of CAMLs in cancer management.
  • To address knowledge gaps regarding CAML detection, origin, and function.

Main Methods

  • Literature review of existing CAML research.
  • Analysis of studies reporting CAML detection in cancer patients.
  • Discussion of the implications for clinical decision-making.

Main Results

  • CAMLs are detectable in blood samples from patients with lung, pancreas, breast, oesophageal, and colorectal cancers.
  • CAMLs have not been identified in healthy individuals.
  • Optimal detection methods, origin, and function require further investigation.

Conclusions

  • CAMLs show promise as liquid biopsy biomarkers for cancer prognostication and monitoring treatment response.
  • Further research is needed to fully elucidate their role and optimize detection for clinical application.
  • CAMLs could guide clinical decision-making in solid tumor management.

Keywords:

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