Adult-Onset Still's Disease (AOSD) in Patient with Previous Lyme Disease

Adult-onset Still's Disease (AOSD) is a rare autoimmune disorder causing systemic inflammation that presents with a rash, fever, polyarthritis, and a characteristic serum hyperferritinemia. There is a complex relationship between infections and autoimmune disease, however, the association of AOSD with lyme disease is not well established. Here we present a case of AOSD in a 29-year-old male with a recent history of lyme disease. After ruling out infection and malignancy, a diagnosis of AOSD was made. From this report, we aim to raise more awareness for AOSD and recommend providers consider this diagnosis as a potential sequela of lyme disease.