Related Experiment Video
Updated: May 24, 2025
09:56
Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
Published on: April 30, 2019
6.5K
Emergent Stable Tissue Shapes from the Regulatory Feedback between Morphogens and Cell Growth
Bivash Kaity1, Daniel Lobo1,2
1Department of Biological Sciences, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.
Biorxiv : the Preprint Server for Biology
|March 3, 2025
Summary
This study reveals how feedback between cell behavior and mechano-chemical signals drives tissue growth and pattern formation. Integrating these signals is key for multicellular organisms to achieve stable shapes and spatial organization.
Area of Science:
- Developmental Biology
- Systems Biology
- Mathematical Biology
Background:
- Multicellular organism development relies on coordinated cellular behaviors and mechano-chemical signals.
- The integration mechanisms linking these signals to emergent tissue shapes are not fully understood.
Purpose of the Study:
- To investigate the feedback mechanisms governing tissue growth and pattern formation using a novel mathematical model.
- To elucidate how mechano-chemical signaling and cellular dynamics interact to regulate tissue morphogenesis.
Main Methods:
- Developed a cell-centered agent-based mathematical model.
- Incorporated cell size dynamics influenced by morphogen concentrations and mechanical stress.
- Model does not rely on a superimposed lattice for increased applicability.
Main Results:
- Demonstrated that integrating feedback loops between cellular behaviors and mechano-chemical signaling is crucial for tissue shape and pattern regulation.
- Showed that patterning processes, like Turing systems, can induce stable tissue shapes that feedback to morphogen patterning.
- Highlighted the self-regulated loop between tissue shape and morphogenetic signals.
Conclusions:
- Emphasized the critical role of the feedback loop between morphogen patterning and cellular behaviors in regulating tissue growth and stable shape.
- Established a framework for high spatiotemporal resolution models to study whole-body development and regeneration.
Keywords:
Agent-based modelingComputational morphogenesisEmergent tissue shapesMechanochemical feedbackMorphogenesis and patterningMorphogenetic feedback loopMultiscale modelingTissue growth dynamicsMore Related Videos
Related Concept Videos
02:19Morphogenesis
24.6K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
24.6K
02:36Cells Coordinate Growth and Proliferation
4.4K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.4K
01:24Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
01:19Cell Migration
4.7K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
4.7K
03:14Notch Signaling Pathway
4.2K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.2K
01:28The Cell Cycle Control System
2.5K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
2.5K