Related Experiment Video
Updated: Aug 4, 2026

Facile Preparation of Ultrafine Aluminum Hydroxide Particles with or without Mesoporous MCM-41 in Ambient Environments
Published on: May 11, 2017
Pharmacodynamic and pharmacokinetic correlation of muzolimine with and without aluminium hydroxide
Abstract:
The objective of the reported study was to investigate whether aluminium hydroxide administered in addition to muzolimine interferes with the pharmacodynamics or the pharmacokinetics of the drug. For this purpose a cross-over study in 6 healthy male volunteers was carried out in which each subject received muzolimine and after a wash-out period muzolimine together with Aludrox. To avoid interferences of a psychological nature a third period with placebo was added. The administrations were randomised. The excreted urinary volume was measured, and blood was taken at relevant times in order to follow the pharmacokinetic profile. These are the results: Urinary excretion after the oral administration of muzolimine was within normal limits compared with the literature. There was no change in elimination with respect to either extent or time characteristics after the combined administration of Aludrox. There was no change in the pharmacokinetic profile either.
More Related Videos
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
08:31Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
Published on: October 11, 2019
Related Concept Videos
Factors Influencing Drug Absorption: Disease States and Pharmacology
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles in drug...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship