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Exploratory analyses of the associations between Ki-67 expression, lymph node metastasis, and prognosis in patients with esophageal squamous cell cancer

  • 0Department of Radiation Oncology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Peerj +

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March 3, 2025

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March 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

High Ki-67 expression in esophageal squamous cell cancer (ESCC) indicates a poorer prognosis and increased risk of metastasis. This finding suggests Ki-67 may guide adjuvant therapy decisions for ESCC patients.

Area Of Science

  • Oncology
  • Cancer Biomarkers
  • Esophageal Cancer Research

Background

  • The prognostic significance of Ki-67 protein expression in esophageal squamous cell cancer (ESCC) remains incompletely understood.
  • Investigating the association between Ki-67 expression, lymph node metastasis (LNM), vascular invasion (VI), and perineural invasion (PI) is crucial for ESCC patient management.

Purpose Of The Study

  • To evaluate the prognostic value of Ki-67 protein expression in patients with resected ESCC.
  • To assess the association between Ki-67 expression and clinicopathological features, including LNM, VI, and PI in ESCC.

Main Methods

  • Retrospective cohort study including 168 patients with ESCC.
  • Patients categorized into high (n=93) and low (n=75) Ki-67 expression groups.
  • Statistical analyses included chi-square tests, Kaplan-Meier survival analysis, and Cox proportional hazards models.

Main Results

  • High Ki-67 expression was significantly associated with poor overall survival (OS) in both univariate (HR=3.42) and multivariate (HR=1.98) analyses.
  • High Ki-67 expression correlated with an increased risk of LNM (P=0.011), VI (P=0.012), and PI (P=0.003).

Conclusions

  • Elevated Ki-67 protein expression is a significant indicator of poor prognosis in ESCC.
  • Increased Ki-67 expression is linked to higher risks of LNM, VI, and PI, suggesting its potential role in guiding adjuvant therapy decisions for ESCC.

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