Ultrasound-Guided Percutaneous Microwave Coagulation Studies on VX2 Rabbit Models for Breast Cancer Treatment and...

Area of Science:

• Oncology
• Medical Imaging
• Surgical Technology

Background:

• VX2 breast carcinoma in rabbits serves as a model for studying breast cancer.
• High-frequency ultrasound (US) allows detailed visualization of tumor morphology and hemodynamics.
• Percutaneous microwave coagulation (PMC) is an emerging minimally invasive treatment modality.

Purpose of the Study:

• To investigate the tissue morphology and hemodynamics of rabbit VX2 breast carcinoma using high-frequency ultrasound.
• To evaluate the effectiveness and safety of US-guided percutaneous microwave coagulation (PMC) therapy for VX2 breast tumors.

Main Methods:

• Color Doppler ultrasound assessed tumor growth, blood supply, and hemodynamic parameters weekly for six weeks.
• US-guided PMC was performed on ten rabbits, with ten serving as controls.
• Therapeutic efficacy was evaluated through tumor growth, survival rates, metastasis, and histopathology.

Main Results:

• Tumor growth rate peaked at 463.09% between weeks 2-3, when PMC was initiated.
• Post-ablation, tumors significantly reduced or became undetectable, with no detected blood flow signals.
• Survival rates at 2 and 3 months were 100% and 70% in the treatment group versus 10% and 0% in controls; metastatic rates were 10% and 30% versus 90% and 100%.

Conclusions:

• US imaging effectively monitored VX2 breast carcinoma proliferation and metastasis.
• US-guided percutaneous microwave ablation is a safe, effective, and minimally invasive treatment for rabbit breast cancer.
• This approach shows potential for clinical application in human breast cancer treatment.