Related Experiment Video
Updated: May 24, 2025

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
Published on: June 24, 2016
Asptertides A-H, C13-Polyketides From a Marine-Derived Aspergillus terreus
Yue-Wei Xu1,2, Zhi-Pu Yu2,3,4, Xiang-Yu Liu2
1Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
None:
In the present study, 11 C13-polyketides comprising a monocyclic skeleton of an aromatic (1-6 and 11) or a cyclohexanone moiety (7) and an oxygenated bicyclic nucleus (8-10) were isolated from a mutated strain of endophytic fungus Aspergillus terreus RA2905. Five pairs of enantiomers (2a/b-5a/b and 7a/b) were achieved by chiral-phase HPLC separation. The structures of previously unreported asptertides A-H (1-8) were determined by analysis of the spectroscopic data and electronic circular dichroism (ECD) calculations. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging bioassays revealed that some compounds showed moderate antioxidant effects, with IC50 values ranging from 13.7 to 35.6 µM.
Related Concept Videos
Amino acids
Allosteric Proteins-ATCase
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
Basicity of Heterocyclic Aromatic Amines
Structure of Amines
Caspases
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group...

