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[Massive skeletal fluorosis in compromised kidney function].

C W Schmidt, P Würgatsch, E Auermann

    Zeitschrift Fur Urologie Und Nephrologie
    |March 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    This case report highlights skeletal fluorosis in an elderly man due to chronic fluoride exposure exacerbated by kidney insufficiency. It emphasizes monitoring renal function during fluoride therapy.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Skeletal Diseases

    Background:

    • Chronic kidney disease (CKD) can impair fluoride excretion, increasing the risk of toxicity.
    • Arteriosclerosis is a common comorbidity in the elderly, often leading to renal insufficiency.
    • Fluoride has therapeutic uses but requires careful dosage, especially in patients with compromised renal function.

    Observation:

    • An 86-year-old male patient presented with severe skeletal fluorosis.
    • The patient had a history of arteriosclerosis leading to renal insufficiency.
    • The skeletal fluorosis developed secondary to chronic fluoride exposure.

    Findings:

    • Massive skeletal fluorosis was diagnosed in the patient.
    • Renal insufficiency was identified as the primary factor enabling fluoride accumulation.

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  • Chronic exposure to fluorides, even at levels not typically considered toxic, led to severe disease in this context.

    • Implications:

    • This case underscores the critical need to assess renal functional parameters before and during fluoride therapy.
    • Understanding the interplay between renal function and fluoride metabolism is crucial for preventing iatrogenic fluorosis.
    • Clinicians should exercise caution when prescribing fluoride-containing medications or treatments to elderly patients with or at risk for renal impairment.