Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Receptors: Overview01:22

Opioid Receptors: Overview

422
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
422
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

204
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
204
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

160
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
160
Analgesia and Pain Management01:25

Analgesia and Pain Management

422
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
422
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

365
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
365
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

777
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
777

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shared Decision-Making in CKD: Lessons From Advance Care Planning in Taiwan.

Kidney medicine·2026
Same author

The cost of dementia in the United States in 2026.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Improving Clinical Trials Reporting in Medicare Claims.

JAMA health forum·2026
Same author

Human peripheral nerve xenografts and rat peripheral nerve allografts implanted to the striatum: Methodology and initial findings of cell-based therapy.

Journal of neuroscience methods·2026
Same author

Recent minimum wage policies and their association with suicide and poisoning deaths.

American journal of epidemiology·2026
Same author

The typhoid Mary legacy: Genomic epidemiology uncovers contemporary carriage dynamics across two decades of enteric fever surveillance in England and Wales.

PLoS neglected tropical diseases·2026

Related Experiment Video

Updated: May 24, 2025

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

2.0K

Naloxone Knowledge, Carrying, Purchase, and Use.

Mireille Jacobson1, David Powell2

  • 1University of Southern California, Los Angeles.

JAMA Network Open
|March 3, 2025
PubMed
Summary

Most individuals with opioid dependence know about and carry naloxone, often without purchasing it. This highlights the need for innovative methods, like online surveys, to track naloxone possession effectively.

Area of Science:

  • Public Health
  • Epidemiology
  • Pharmacology

Background:

  • Widespread naloxone access is crucial for addressing the opioid crisis.
  • Estimates of naloxone availability often rely on pharmacy sales, excluding other distribution channels.

Purpose of the Study:

  • To assess naloxone knowledge, carrying behaviors, purchase history, and administration among US adults.
  • To understand naloxone utilization in a national sample and among individuals with opioid dependence.

Main Methods:

  • A cross-sectional online survey was conducted from June 7-29, 2024.
  • Included noninstitutionalized adults aged 18+ from a national sample and a sample self-reporting opioid dependence.
  • Assessed knowledge, carrying, purchase, and administration of naloxone, with exposures including opioid misuse and overdose risk.

More Related Videos

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

10.9K
Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

54.7K

Related Experiment Videos

Last Updated: May 24, 2025

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

2.0K
Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

10.9K
Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

54.7K

Main Results:

  • A high percentage of respondents with opioid dependence (89.0%) knew naloxone's purpose, and 60.5% carried it, compared to 46.2% and 10.6% in the national sample, respectively.
  • Among those at high risk of overdose or knowing someone at high risk, carrying rates were significantly higher in the opioid-dependent group (73.8% and 70.1%) versus the national sample (31.0% and 25.4%).
  • Most naloxone carried was not purchased; administration rates were higher among those with opioid dependence (47.5% administered, 39.3% received).

Conclusions:

  • Individuals with opioid dependence demonstrate high awareness and carrying of naloxone, often obtained through non-purchase channels.
  • Findings suggest current methods may underestimate naloxone availability and possession.
  • Rapid online surveys offer a viable approach for monitoring naloxone possession and informing public health strategies.