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The association between beta-blockers use and depression - narrative review
Kamila Tokarczyk1, Karolina Sas1, Magdalena Piegza2
1Studenckie Koło Naukowe, Oddział Kliniczny Psychiatrii Katedry Psychiatrii, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach, 42-612 Tarnowskie Góry.
Psychiatria Polska
|March 3, 2025
Summary
Beta-blockers generally do not cause depression in patients with heart disease. While metoprolol may worsen symptoms, other beta-blockers like carvedilol show no link to depression.
Area of Science:
- Cardiology
- Psychiatry
- Pharmacology
Background:
- Depression is common in somatic diseases, worsening cardiovascular health.
- Beta-blockers are widely used for cardiovascular diseases, raising concerns about potential mood side effects.
Purpose of the Study:
- To analyze the impact of beta-blockers on the frequency and severity of depressive symptoms.
- To investigate the central and peripheral effects of commonly used beta-blockers on mood.
Main Methods:
- Review of medical data on commonly used beta-blockers.
- Analysis focused on lipophilicity and central nervous system penetration.
- Consideration of both central and peripheral drug actions.
Main Results:
- Metoprolol was associated with increased depressive symptoms in most studies.
- Carvedilol, bisoprolol, and propranolol did not induce depressive symptoms.
- Beta-blockers showed no significant effect on depression induction; some may prevent it.
- A positive effect on reducing anxiety was noted, alongside potential fatigue and sleep disturbances.
Conclusions:
- Beta-blockers have a clinically insignificant effect on inducing depressive symptoms.
- Specific beta-blockers may offer protective effects against depression or reduce its severity.
- Beta-blockers can reduce anxiety but may cause fatigue and sleep issues.
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