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Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

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Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
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Updated: May 24, 2025

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
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Diffusion Models as Strong Adversaries.

Xuelong Dai, Yanjie Li, Mingxing Duan

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    This study explores diffusion models as adversarial threats, developing a novel no-box attack method using only generated data. The research demonstrates effective adversarial attacks without needing original training data.

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    Area of Science:

    • Artificial Intelligence
    • Computer Vision
    • Machine Learning

    Background:

    • Diffusion models excel at generating high-quality images.
    • Their adversarial capabilities, especially in no-box attack scenarios, remain underexplored.
    • Existing no-box attacks often require access to training data, limiting real-world applicability.

    Purpose of the Study:

    • To investigate the adversarial potential of diffusion models.
    • To propose a novel no-box adversarial attack method using only diffusion model-generated data.
    • To evaluate the attack's effectiveness on the ImageNet dataset.

    Main Methods:

    • Generated a synthetic dataset using diffusion models to train a substitute model.
    • Fine-tuned the substitute model using a classification diffusion model, incorporating model uncertainty and noise augmentation.
    • Sampled adversarial examples via average approximation over the substitute model with multiple inferences.

    Main Results:

    • The proposed method achieves state-of-the-art performance in no-box adversarial attacks.
    • Demonstrated successful adversarial attacks using solely diffusion model-generated data.
    • Validated effectiveness on the challenging ImageNet dataset.

    Conclusions:

    • Diffusion models can be effectively utilized for sophisticated adversarial attacks.
    • The developed no-box attack method offers a practical solution for real-world threat scenarios.
    • This research highlights the dual nature of diffusion models as powerful generative tools and potential security risks.