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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Updated: May 5, 2026

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Neuronavigation-Guided Transcranial Acoustoelectric Brain Imaging: A New Modality for High Resolution Electrical

Margaret Allard, Teodoro Trujillo, Chet Preston

IEEE Transactions on Bio-Medical Engineering

|March 3, 2025

Summary

This summary is machine-generated.

This study demonstrates neuronavigation-guided Transcranial Acoustoelectric Brain Imaging (tABI) can accurately map deep brain electrical currents with high resolution in a human head model.

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Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

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Area of Science:

Neuroimaging
Biophysics
Medical Devices

Background:

Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) have limitations in resolution and accuracy for brain studies.
Transcranial Acoustoelectric Brain Imaging (tABI) offers a novel approach combining focused ultrasound and electrical sensing for high-resolution electrical current mapping.

Purpose of the Study:

To demonstrate the feasibility of integrating tABI with neuronavigation.
To assess the performance of tABI in mapping deep current sources within a human skull model.

Main Methods:

A neuronavigation system with optical tracking and MRI guided the placement of a 2D ultrasound array on a skull model.
Electrical current sources were generated within a conductive gel simulating brain tissue.
4D tABI scans were performed to create volumetric, time-varying electrical maps.

Main Results:

Achieved spatial resolution better than 5 mm for current sources deeper than 20 mm.
Demonstrated a current detection threshold better than 500 μA at 1 MPa.
Image registration error was less than 6.5 mm.

Conclusions:

Neuronavigation-guided tABI enables accurate, high-resolution detection of deep electrical current sources.
This advancement is a significant step towards noninvasive electrical brain imaging in humans.