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Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression

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Related Experiment Video

Updated: Jun 13, 2026

Animal Models of Depression - Chronic Despair Model CDM
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WavFace: A Multimodal Transformer-Based Model for Depression Screening.

Ricardo Flores, M L Tlachac, Avantika Shrestha

    IEEE Journal of Biomedical and Health Informatics
    |March 3, 2025
    PubMed
    Summary

    WavFace, a deep learning model, effectively screens for depression using audio and facial cues from virtual interviews. This innovative approach achieves high accuracy, offering a promising tool for mental health assessment.

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    Area of Science:

    • Artificial Intelligence
    • Mental Health Technology
    • Computational Psychiatry

    Background:

    • Depression is a widespread mental health disorder with significant health and economic impacts.
    • Current depression detection methods can be costly and challenging.
    • Deep learning (DL) models show potential for depression screening using clinical interview videos.

    Purpose of the Study:

    • To develop a multimodal deep learning model for accurate depression screening.
    • To address challenges in modality representation, alignment, fusion, and small sample sizes in DL models.
    • To propose WavFace, a novel model integrating audio and temporal facial features.

    Main Methods:

    • Developed WavFace, a multimodal deep learning model using audio and temporal facial features.
    • Incorporated an encoder-transformer layer for enhanced unimodal representation.
    • Implemented explicit alignment and sequential/spatial self-attention for modality fusion.
    • Modeled after clinical observations of visual and vocal cues in mental health assessments.

    Main Results:

    • WavFace demonstrated superior performance compared to existing unimodal and multimodal DL models.
    • Achieved a balanced accuracy of 0.81 in depression screening using a single interview question.
    • Successfully integrated audio and visual data for robust mental health screening.

    Conclusions:

    • WavFace offers a valuable and effective modeling approach for audio-visual mental health screening.
    • The model's ability to process multimodal data enhances depression detection accuracy.
    • This research contributes to advancing AI-driven tools for mental health assessment.