Physical compatibility of ceftazidime-avibactam with selected intravenous antimicrobials in simulated Y-site...

Area of Science:

• Pharmacology and Pharmaceutical Sciences
• Clinical Pharmacy
• Infectious Diseases

Background:

• Ceftazidime-avibactam is a crucial antibiotic for treating multidrug-resistant Gram-negative infections.
• Simultaneous administration of intravenous drugs via Y-sites is common in clinical practice.
• Assessing physical compatibility is essential to prevent drug-related complications.

Purpose of the Study:

• To evaluate the physical compatibility of ceftazidime-avibactam with selected intravenous antimicrobials.
• To determine the safety of co-administering ceftazidime-avibactam with other commonly used antibiotics through Y-sites.

Main Methods:

• Ceftazidime-avibactam was mixed with tigecycline, metronidazole, meropenem, imipenem-cilastatin, fosfomycin, aztreonam, and vancomycin.
• Admixtures were assessed at 0, 1, 2, and 4 hours for visual changes, Tyndall beam, turbidity, pH, spectroscopic absorption, and particle counts.
• Simulated Y-site administration conditions were used at room temperature.

Main Results:

• No visual signs of incompatibility were observed in any of the ceftazidime-avibactam admixtures.
• Turbidity, Tyndall beam, pH, spectroscopic absorption, and particle counts remained within acceptable limits for all combinations.
• All tested admixtures demonstrated physical compatibility throughout the 4-hour observation period.

Conclusions:

• Ceftazidime-avibactam is physically compatible with tigecycline, metronidazole, meropenem, imipenem-cilastatin, fosfomycin, aztreonam, and vancomycin.
• These findings suggest that ceftazidime-avibactam can be safely co-administered with these antimicrobials via Y-site infusion.
• This compatibility supports flexible and efficient therapeutic regimens in clinical settings.