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Published on: May 2, 2018
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Microbiota-derived metabolites in inflammatory bowel disease
Martina A Guggeis1,2, Danielle Mm Harris1,2,3, Lina Welz1,2
1Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Rosalind Franklin Straße 11, Campus Kiel, 24105, Kiel, Germany.
Seminars in Immunopathology
|March 3, 2025
Summary
Altered gut microbes and their metabolites impact inflammatory bowel diseases (IBD). Personalized supplementation strategies, based on individual gut profiles, offer new therapeutic potential for IBD patients.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- Inflammatory bowel diseases (IBD) are linked to gut microbiota alterations.
- Taxonomic studies alone have yielded inconsistent findings in IBD.
- Research is shifting towards microbial metabolites and their immunomodulatory roles.
Purpose of the Study:
- To review the role of gut microbial metabolites in IBD pathogenesis.
- To highlight beneficial metabolites often decreased in IBD.
- To propose personalized, multi-omics-based therapeutic strategies for IBD.
Main Methods:
- Literature review focusing on microbial metabolites in IBD.
- Analysis of studies investigating metabolite-host-microbiota interactions.
- Synthesis of findings on metabolite-based therapeutic potential.
Main Results:
- Metabolic profiles are significantly altered in IBD patients.
- Specific metabolites play a causative role in immune modulation in animal models.
- Beneficial metabolites are generally found at lower levels in IBD.
Conclusions:
- Understanding microbiota-metabolite-host communication is key for IBD biomarkers and therapies.
- Current IBD therapies lack large-scale breakthroughs.
- Personalized microbiota and metabolite supplementation, guided by multi-omics data, is a promising approach for IBD treatment.
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