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New Types of Post-Translational Modification of Proteins in Cardiovascular Diseases

Juntao Fang1, Shaoyu Wu1, Hengli Zhao2

  • 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People'S Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.

Journal of Cardiovascular Translational Research
|March 3, 2025
PubMed

Insights

New post-translational modifications (PTMs) like acetylation and lactylation are crucial in cardiovascular diseases (CVDs). Understanding these protein alterations aids in developing novel diagnostic and therapeutic strategies for CVDs.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Post-translational modifications (PTMs) are vital for protein function and cellular homeostasis.
  • The role of PTMs in cardiovascular diseases (CVDs) is increasingly recognized for influencing disease progression.
  • Identifying PTMs in CVDs is key for discovering new biomarkers and therapeutic targets.

Purpose of the Study:

  • To provide a comprehensive overview of emerging PTMs in cardiovascular diseases.
  • To elucidate the mechanisms by which these PTMs affect CVDs.
  • To highlight the potential of PTMs in advancing diagnostic and therapeutic strategies for CVDs.

Main Methods:

  • Literature review of recent studies on PTMs in CVDs.
  • Analysis of the molecular mechanisms underlying PTMs in cardiovascular physiology and pathology.
  • Synthesis of current knowledge on PTMs for clinical applications.

Main Results:

  • Several novel PTMs, including acetylation, crotonylation, succinylation, S-nitrosylation, malonylation, S-palmitonylation, β-hydroxybutyrylation, and lactylation, play significant roles in CVDs.
  • These PTMs impact protein stability, activity, and localization, thereby influencing the development and progression of cardiovascular conditions.
  • Understanding these modifications offers insights into disease mechanisms and potential intervention points.

Conclusions:

  • Emerging PTMs represent a critical area of research in cardiovascular diseases.
  • Further investigation into these modifications can lead to the development of innovative biomarkers and therapeutic targets.
  • This knowledge is essential for advancing the diagnosis and treatment of CVDs.
Keywords:
Cardiovascular diseasesCrotonylationLactylationPost-translational modificationsSuccinylation

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