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Diagnostic value of peripheral blood inflammatory indices for clinicopathological profile of colorectal cancer: a retrospective observational study

  • 0Student Research Committee, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mohammad.r.g1381@gmail.com.
Bmc Gastroenterology +

|

March 3, 2025

|

March 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Elevated Systemic Inflammation Response Index (SIRI) is linked to metastasis, while higher Cancer-Inflammation Prognostic Index (CIPI) correlates with advanced colorectal cancer stages. These inflammatory markers aid early diagnosis and personalized treatment.

Area Of Science

  • Oncology
  • Inflammation Biomarkers
  • Diagnostic Accuracy

Background

  • Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide.
  • Early diagnosis and understanding clinicopathological characteristics are crucial for effective CRC management.
  • Peripheral blood inflammatory indices offer potential for non-invasive diagnostic tools.

Purpose Of The Study

  • To evaluate the diagnostic value of several peripheral blood inflammatory indices in the early detection of colorectal cancer (CRC) clinicopathological features.
  • To assess the association between indices like CIPI, SIRI, HALP, NLR, and PLR with CRC metastasis and tumor stage.

Main Methods

  • Retrospective observational study of 224 CRC patients over 45 years old.
  • Collection of demographic, clinicopathological data, and blood samples to calculate inflammatory indices.
  • Univariate, multivariate, and ROC analyses to determine predictors of metastasis and stage.

Main Results

  • Elevated SIRI levels significantly associated with metastasis (OR=2.79) in univariate analysis.
  • CIPI significantly associated with advanced tumor stages (OR=1.97) in multivariate analysis.
  • ROC analysis indicated optimal SIRI cut-off for metastasis and CIPI cut-off for tumor stage.

Conclusions

  • Higher SIRI values correlate with increased risk of metastasis in CRC patients.
  • Higher CIPI values are associated with advanced tumor stages, suggesting prognostic value.
  • Integration of these inflammatory indices into clinical practice can improve early diagnosis and personalized CRC treatment strategies.

Keywords:

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