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Midface Toddler Excoriation Syndrome (MiTES): A Review.

Varniraj Patel¹, Deepika Yadav², Maitri Patel³

¹Department of Dermatology, Venereology and Leprology, All India Institute of Medical Sciences, Rajkot, Gujarat, India.

Pediatric Dermatology

|March 4, 2025

Summary

Midface toddler excoriation syndrome (MiTES) is a rare genetic skin condition in children. This review covers its features, PRDM12 gene link, and varied treatment outcomes.

Keywords:

behavioral dermatology genetic analysis midface scarring multidisciplinary management self‐inflicted lesions

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Area of Science:

Dermatology
Genetics
Pediatrics

Background:

Midface toddler excoriation syndrome (MiTES) is a rare dermatological condition.
Characterized by chronic, self-inflicted midface excoriations, leading to scarring and hyperpigmentation.
Primarily affects young children, with a notable male predominance.

Purpose of the Study:

To consolidate current knowledge on MiTES.
To emphasize its clinical features, genetic basis, and management strategies.

Main Methods:

This is a review article.
Consolidates existing literature on MiTES.

Main Results:

MiTES is linked to genetic mutations in the PRDM12 gene.
Current treatments include topical antimicrobials, emollients, steroids, and oral medications.
Treatment responses are inconsistent, with many patients experiencing only partial improvement.

Conclusions:

MiTES presents unique clinical and genetic challenges.
Further research is needed to optimize treatment strategies for MiTES.
Understanding the PRDM12 gene link is crucial for future therapeutic development.