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Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

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Programmable Control of Active Ingredient Release in Pickering Emulsions Using Light.

Jie Liu¹, Zichun Song¹, Jing Luo¹

¹Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu, 214122, China.

Small (Weinheim an Der Bergstrasse, Germany)

|March 4, 2025

Summary

This study introduces light-responsive nanogates in Pickering emulsions for controlled release. UV light triggers the opening of these nanogates, enabling programmable delivery of active substances without disrupting the emulsion.

Keywords:

azo‐benzene oil‐water interface pickering emulsion programable release

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Area of Science:

Colloid and Surface Science
Materials Science
Nanotechnology

Background:

Pickering emulsions are vital for delivering active ingredients in diverse fields like pharmaceuticals and cosmetics.
Current methods for releasing encapsulated substances often require emulsion disruption, posing a challenge for programmable release.
A need exists for non-invasive, controlled release mechanisms for active ingredients within stable emulsion systems.

Purpose of the Study:

To develop a Pickering emulsion system with a light-responsive colloidal layer acting as nanogates.
To demonstrate programmable release of encapsulated active substances using UV light as a remote stimulus.
To investigate the control over release kinetics by adjusting system parameters.

Main Methods:

Fabrication of a colloidal layer with azobenzene-functionalized silica particles at the oil-water interface.
Utilizing UV and visible light to induce cis-trans isomerization of azobenzene, controlling inter-particle gaps (nanogates).
Monitoring the release of a model active substance (perylene) under controlled light irradiation cycles.

Main Results:

Demonstrated a 'nanogate' effect where UV irradiation opened gaps between colloidal particles.
Achieved programmable release of perylene from Pickering emulsion droplets triggered by UV light.
Showcased precise control over perylene release amount by tuning particle size and light exposure duration, maintaining emulsion stability.

Conclusions:

Developed a novel Pickering emulsion system with light-activated nanogates for programmable release.
The system offers non-invasive, remote control over active substance release using UV-visible light.
Presents a versatile platform for applications in food, cosmetics, and pharmaceuticals requiring controlled delivery.