Penile metastasis from a duodenal gastrointestinal stromal tumor: A rare case report
Fumiya Yoneyama1, Teppei Okamoto1, Tomoko Hamaya1
1Department of Urology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
Abstract:
Penile metastases are rare, and metastasis of a gastrointestinal stromal tumor (GIST) to the penis is exceedingly uncommon. An 81-year-old man with a history of duodenal GIST, initially treated with curative resection and tyrosine kinase inhibitor therapy for liver metastasis, presented with an enlarging penile mass. A biopsy confirmed penile metastasis from GIST. To relieve his symptoms, a total penectomy was performed. Molecular testing revealed a KIT exon 9 mutation and CDKN2A/B gene alterations, indicating aggressive tumor behavior and resistance to standard treatment. This case underscores the importance of recognizing atypical metastatic sites in GIST.
Insights
Gastrointestinal stromal tumors (GIST) rarely spread to the penis. This case highlights an unusual penile metastasis from GIST, emphasizing the need to consider rare sites for GIST spread.
Area of Science:
- Oncology
- Gastroenterology
- Urology
Background:
- Penile metastases are rare clinical occurrences.
- Gastrointestinal stromal tumors (GIST) are uncommon sarcomas.
- Metastasis of GIST to the penis is exceedingly rare.
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