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Related Experiment Videos

The developmental field concept.

J M Opitz

    American Journal of Medical Genetics
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Embryonic development involves integrated units responding to various causes of anomalies. These units, acting similarly in normal development and across species, reveal evolutionary connections in anatomical structures.

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    Area of Science:

    • Developmental Biology
    • Evolutionary Biology
    • Teratology

    Background:

    • Identical anomalies can arise from diverse factors like aneuploidy, gene mutation, and teratogens.
    • Embryonic primordia (developing tissues) respond uniformly to stimuli causing malformations.
    • This suggests these units also function cohesantly during normal embryonic development (ontogeny).

    Purpose of the Study:

    • To investigate the concept of embryonic units in development and malformation.
    • To explore the implications of conserved malformations across species for homology.
    • To connect experimental embryology's 'fields' with broader developmental processes.

    Main Methods:

    • Comparative analysis of malformations across different causes and species.
    • Conceptual integration of experimental embryology with evolutionary and developmental biology.

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  • Examination of the role of embryonic units in both normal and abnormal development.

    • Main Results:

    • Identical anomalies from disparate causes indicate embryonic primordia act as integrated units.
    • Conserved malformations across mammalian species suggest developmental and anatomical homology due to common ancestry.
    • These reactive units are analogous to experimental embryology's 'epimorphic fields'.

    Conclusions:

    • Embryonic primordia function as coordinated units during both normal and abnormal development.
    • The concept of 'fields' in experimental embryology is supported by observations of conserved developmental units.
    • Understanding these units provides insight into phylogenetic and species-specific genetic control of development.